Stanford Tumor Glycome Laboratory

An NCI-funded Tumor Glycome Laboratory
NCI 资助的肿瘤糖组学实验室

Director: Denong Wang, MD, PhD

实验室主任:王德农,医師,博士

Our laboratory is one of the seven NCI-funded Tumor Glycome Laboratories, the principal component of the new trans-NIH Alliance of Glycobiologists for Detection of Cancer and Cancer Risk.

我们的实验室是NIC資助的七家肿瘤糖组学实验室之一。
这七家实验室是國立衛生研究所新建的肿瘤監測與
腫瘤風險研究糖生物學家多部门聯盟的主要组成部分。

Our research team is formed by investigators who have established research track records in high-throughput platforms of carbohydrate microarrays, neoglycolipid (NGL) technology coupled with mass spectrometry for carbohydrate ligand discovery, flow cytometry (Hi-D FACS) for highly sensitive detection of cell and serum markers, and the first international standard for detection of serum prostate-specific antigen (PSA).

我们的研究团队成员在下列研究领域已有建設性成果: 建立糖分子生物芯片的高通量技術平台, 新組糖 (NGL)與質谱並聯進行糖分子配体開發, 应用流式細胞仪(多指標FACS)進行高靈敏度細胞及血清標誌物測定, 以及建立前列腺特异的抗原血清測定的第一個国际标准。

The thrust of our research team is identification and characterization of carbohydrate-based immunological markers of human cancers, as well as development of highly sensitive assays for clinical and research applications. Our current research focus is glycan markers of prostate cancers and anti-glycan autoantibody signatures in prostate cancer patients. Our investigators are assembled as four basic components and function as a team in pursuing these goals. Key personnel of each component are listed below:

我们研究团队擅長于发现和鉴定人类肿瘤细胞糖分子的免疫标记並開發可用于临床的高灵敏检测方法
。我们当前的研究重点在前列腺肿瘤多糖标记和前列腺肿瘤病人的抗多糖自身抗体信号。
我们的研究者主要有四个基本的部门组成,
形成了一个团队致力于我们研究目标的实现。每个部门的关键人员在下面的名单中:

Biomarker Discovery Component

生物标记開发部門

Denong Wang, MD, PhD, Director(Tumor Glycome), genetics, Stanford University
Leonard A. Herzenberg, PhD, professor emeritus in genetics; co-investigator, genetics, Stanford University
Denong Wang 医師,博士,責任研究者,遗传学,斯坦福大学
Leonard A. Herzenberg 博士,遗传学名誉教授,联合研究者,遗传学,斯坦福大学

Carbohydrate Analytical Component

碳水化合物分析部门

Ten Feizi, MD., co-investigator, Imperial College London
医学博士,副責任研究者,伦敦帝国大学

Clinical Specimen Component

临床样品部门

Donna Peehl, PhD, professor of urology; co-investigator, urology, Stanford University
博士,泌尿学教授,联合研究者,泌尿学,斯坦福大学

Statistical Support Component

统计支持部门

Philip W. Lavori, PhD, professor of health research and policy; co-investigator, Cancer Center, Stanford University
博士,健康研究和政策教授,联合研究者,肿瘤中心,斯坦福大学
Marc A. Coram, PhD, Assistant Professor of health research and policy, Collaborator, Cancer Center, Stanford University
博士,健康研究和政策助理教授,合作研究者,肿瘤中心,斯坦福大学

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